MENU
Home Home Home
 

Quantifying dynamic mechanical properties of human placenta tissue using optimization techniques with specimen-specific finite-element models

In: Journal of Biomechanics. Vol. 42, issue 15 (Nov. 13, 2009), p. 2528-2534.

Authors: Jingwen Hu, Kathleen D. Klinich, Carl S. Miller, Giseli Nazmi, Mark D. Pearlman, Lawrence W. Schneider, Jonathan D. Rupp.

Motor-vehicle crashes are the leading cause of fetal deaths resulting from maternal trauma in the United States, and placental abruption is the most common cause of these deaths. To minimize this injury, new assessment tools, such as crash-test dummies and computational models of pregnant women, are needed to evaluate vehicle restraint systems with respect to reducing the risk of placental abruption. Developing these models requires accurate material properties for tissues in the pregnant abdomen under dynamic loading conditions that can occur in crashes. A method has been developed for determining dynamic material properties of human soft tissues that combines results from uniaxial tensile tests, specimen-specific finite-element models based on laser scans that accurately capture non-uniform tissue-specimen geometry, and optimization techniques. The new method provides a nearly 40% error reduction (p<0.001) compared to traditional curve-fitting methods by considering detailed specimen geometry, loading conditions, and dynamic effects from high-speed loading. The proposed method can be applied to determine mechanical properties of other soft biological tissues.

Research Group: